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Mouse cd113 (aa 58 – 404)

Pvrl3 Swiss Prot#

Q9JLB9

Pvrl3 Protein names

Poliovirus receptor-related protein 3 (Nectin-3) (CD antigen CD113)

Pvrl3 Gene names

Pvrl3

Organism

Mouse

Pvrl3 Entry name

PVRL3_MOUSE

Pvrl3 Codon optimized cDNA(gene) Clone

Pvrl3 Cat #

RPV0056

Tag

Pvrl3 contains A 6x histidine tag

Pvrl3 Formulation

Liquid

Pvrl3 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Pvrl3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Pvrl3 Protein

Pvrl3 Cat #

PV0056

Pvrl3 Source

recombinant.

Pvrl3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Pvrl3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Pvrl3 Activity

N/A

Tag

Pvrl3 Contains A 6x histidine tag

Pvrl3 Formulation

Liquid

Pvrl3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Pvrl3 family

SUBUNIT: Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interacts with MLLT4/afadin. Binds with low affinity to TIGIT.

Pvrl3 Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein (Potential).

Pvrl3 FUNCTION According to UniProtKB Swiss Prot

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Pvrl3 Sequence

DDBJ

EMBL

GenBank

Pvrl3 3D structure

ModBase

Pvrl3 interaction

STRING

Pvrl3 Proteomic

PRIDE

Pvrl3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Pvrl3 Organism specific

CTD

MGI

Pvrl3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Pvrl3 Gene expression

Bgee

ArrayExpress

Genevestigator

Pvrl3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY