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Human cd113 (aa 58 – 404)

PRR3 Swiss Prot#

Q9NQS3

PRR3 Protein names

Poliovirus receptor-related protein 3 (CDw113) (Nectin-3) (CD antigen CD113)

PRR3 Gene names

PVRL3 PRR3

Organism

Human

PRR3 Entry name

PVRL3_HUMAN

PRR3 Codon optimized cDNA(gene) Clone

PRR3 Cat #

RPV0055

Tag

PRR3 contains A 6x histidine tag

PRR3 Formulation

Liquid

PRR3 Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PRR3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PRR3 Protein

PRR3 Cat #

PV0055

PRR3 Source

recombinant.

PRR3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PRR3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PRR3 Activity

N/A

Tag

PRR3 Contains A 6x histidine tag

PRR3 Formulation

Liquid

PRR3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PRR3 family

SUBUNIT: Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interacts with MLLT4/afadin. Binds with low affinity to TIGIT.

PRR3 Subcellular locations

SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein (Potential).

PRR3 FUNCTION According to UniProtKB Swiss Prot

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

PRR3 Sequence

DDBJ

EMBL

GenBank

PRR3 3D structure

ModBase

PRR3 interaction

STRING

PRR3 Proteomic

PRIDE

PRR3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PRR3 Organism specific

CTD

MGI

PRR3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PRR3 Gene expression

Bgee

ArrayExpress

Genevestigator

PRR3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY