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STRP2 Pneumolysin (aa 61-471)

Pneumolysin Swiss Prot#

Q04IN8

Pneumolysin Protein names

Pneumolysin (Thiol-activated cytolysin)

Pneumolysin Gene names

ply (SPD_1726)

Organism

Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)

Pneumolysin Entry name

TACY_STRP2

Pneumolysin Codon optimized cDNA(gene) Clone

Pneumolysin Cat #

RPP0967

Tag

Pneumolysin contains A 6x histidine tag

Pneumolysin Formulation

Liquid

Pneumolysin Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Pneumolysin Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Pneumolysin Protein

Pneumolysin Cat #

PP0967

Pneumolysin Source

recombinant

Pneumolysin Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Pneumolysin Purity

>90%, as determined by SDS-PAGE under reducing conditions

Pneumolysin Activity

N/A

Tag

Pneumolysin Contains A 6x histidine tag

Pneumolysin Formulation

Liquid

Pneumolysin Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Pneumolysin family

Thiol-activated cytolysin family

Pneumolysin Subcellular locations

Secreted. Host cell membrane; Multi-pass membrane protein.

Pneumolysin FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).

Pneumolysin Sequence

DDBJ

EMBL

GenBank

Pneumolysin 3D structure

ModBase

Pneumolysin interaction

STRING

Pneumolysin Proteomic

PRIDE

Pneumolysin Genome annotation

Ensembl

GeneID

KEGG

UCSC

Pneumolysin Organism specific

CTD

MGI

Pneumolysin Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Pneumolysin Gene expression

Bgee

ArrayExpress

Genevestigator

Pneumolysin Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY